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  2. Heparin-induced thrombocytopenia - Wikipedia

    en.wikipedia.org/wiki/Heparin-induced...

    Up to 8% of patients receiving heparin are at risk to develop HIT antibodies, but only 1–5% on heparin will progress to develop HIT with thrombocytopenia and subsequently one-third of them may develop arterial or venous thrombosis. [1] After vascular surgery, 34% of patients receiving heparin developed HIT antibodies without clinical symptoms ...

  3. Blood compatibility testing - Wikipedia

    en.wikipedia.org/wiki/Blood_compatibility_testing

    The discrepancy can be resolved by testing the person's red blood cells with an anti-A 1 reagent, which will give a negative result if the patient belongs to the A 2 subgroup. Anti-A 1 antibodies are considered clinically insignificant unless they react at 37 °C (99 °F). Other subgroups of A exist, as well as subgroups of B, but they are ...

  4. Panel-reactive antibody - Wikipedia

    en.wikipedia.org/wiki/Panel-reactive_antibody

    A panel-reactive antibody (PRA) is a group of antibodies in a test serum that are reactive against any of several known specific antigens in a panel of test leukocytes or purified HLA antigens from cells. It is an immunologic metric routinely performed by clinical laboratories on the blood of people awaiting organ transplantation. [1]

  5. Complementarity-determining region - Wikipedia

    en.wikipedia.org/wiki/Complementarity...

    A single antibody molecule has two antigen receptors and therefore contains twelve CDRs total. There are three CDR loops per variable domain in antibodies. Sixty CDRs can be found on a pentameric IgM molecule, which is composed of five antibodies and has increased avidity as a result of the collective affinity of all antigen-binding sites combined.

  6. Autoimmune hepatitis - Wikipedia

    en.wikipedia.org/wiki/Autoimmune_hepatitis

    Incidence 1-2 per 100,000 per year Prevalence 10-25 per 100,000 Autoimmune hepatitis , formerly known as lupoid hepatitis , plasma cell hepatitis , or autoimmune chronic active hepatitis , is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells , causing the liver to be inflamed.

  7. Immunoperoxidase - Wikipedia

    en.wikipedia.org/wiki/Immunoperoxidase

    Immunoperoxidase is a type of immunostain used in molecular biology, medical research, and clinical diagnostics.In particular, immunoperoxidase reactions refer to a sub-class of immunohistochemical or immunocytochemical procedures in which the antibodies are visualized via a peroxidase-catalyzed reaction.

  8. Anti-apolipoprotein antibodies - Wikipedia

    en.wikipedia.org/wiki/Anti-Apolipoprotein_antibodies

    In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β 2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and are strongly associated with thrombotic forms of lupus. [ 1 ]

  9. Hypervariable region - Wikipedia

    en.wikipedia.org/wiki/Hypervariable_region

    In the case of antibodies, an HVR is where most of the differences among antibodies occur. This region is also called the complementarity-determining region. [1] Because there already is a separate article for the antibody region, this article will focus on the nucleic acid case.