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Cryopreservation of ovarian tissue is of interest to women who want fertility preservation beyond the natural limit, or whose reproductive potential is threatened by cancer therapy, [1] for example in hematologic malignancies or breast cancer. [2]
Those with ovarian diseases such as Polycystic Ovary Syndrome could opt for this method. [citation needed] Oocyte cryopreservation is one of many options for individuals undergoing IVF. In some cases, persons may prefer oocyte cryopreservation over other options, where freezing embryos is the primary procedure.
Those with female partners donor sperm may be required, the embryo can then be transferred to the partners uterus. [25] Individuals with male partners can use partner's sperm but will need a surrogate to carry the embryo. [25] Ovarian tissue cryopreservation Can be carried out at the same time as sex reassignment surgery. [25]
An artificial ovary is a potential fertility preservation treatment that aims to mimic the function of the natural ovary. Conventional fertility preservation for females involves oocyte cryopreservation or ovarian tissue cryopreservation. However, there are drawbacks to these treatments.
TVOR is typically performed after ovarian hyperstimulation, where oocytes are pharmacologically stimulated to mature. When the ovarian follicles have reached a certain degree of development, induction of final oocyte maturation is performed, generally by an intramuscular or subcutaneous injection of human chorionic gonadotropin (hCG). [10]
The therapy, Elahere, was being tested in patients with a type of cancer that affects the ovaries, fallopian tube or walls of the abdomen, and who have received at least two prior lines of treatment.
Cryopreservation or cryoconservation is a process where biological material - cells, tissues, or organs - are frozen to preserve the material for an extended period of time. [1] At low temperatures (typically −80 °C (−112 °F) or −196 °C (−321 °F) using liquid nitrogen ) any cell metabolism which might cause damage to the biological ...
Ovarian culture is an in-vitro process that allows for the investigation of the development, toxicology and pathology of the ovary. [1] This technique can also be used to study possible applications of fertility treatments e.g. isolating oocytes from primordial ovarian follicles that could be used for fertilisation.