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Metabolic intermediates are compounds produced during the conversion of substrates (starting molecules) into final products in biochemical reactions within cells. [1]Although these intermediates are of relatively minor direct importance to cellular function, they can play important roles in the allosteric regulation of enzymes, glycolysis, the citric acid cycle, and amino acid synthesis.
Harold Joseph Morowitz (December 4, 1927 – March 22, 2016) was an American biophysicist who studied the application of thermodynamics to living systems. [1] [2] Author of numerous books and articles, his work includes technical monographs as well as essays.
In biochemistry, a metabolite is an intermediate or end product of metabolism. [1] The term is usually used for small molecules.Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and ...
Norman Lowther Edson (1 March 1904 – 12 May 1970), FRSNZ, FNZIC, was the first Professor of Biochemistry (1949–1967) in the University of New Zealand based at the University of Otago, Dunedin, New Zealand where he founded a department of biochemistry.
Schoenheimer's scientific work contributed to biochemistry and metabolic studies, with his most significant work being the application of isotopes to the study of intermediary metabolism. Schoenheimer's earlier scientific work in the 1920s centered on the physiology and pathology of sterols .
Metabolism (/ m ə ˈ t æ b ə l ɪ z ə m /, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks of proteins, lipids, nucleic acids, and some carbohydrates; and the ...
The TCA cycle is a hub of metabolism, with central importance in both energy production and biosynthesis. Therefore, it is crucial for the cell to regulate concentrations of TCA cycle metabolites in the mitochondria. Anaplerotic flux must balance cataplerotic flux in order to retain homeostasis of cellular metabolism. [1]
Conn taught at University of California, Berkeley, from 1950 to 1958, when he joined the University of California, Davis.. With Paul K. Stumpf, Conn co-founded the department of biochemistry and biophysics at Davis and taught an introductory course in biochemistry until his retirement in 1993.