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Prescription niacin preparations in combination with statin drugs (discontinued) are described above. A combination of niacin and laropiprant had been approved for use in Europe and marketed as Tredaptive. Laropiprant is a prostaglandin D2 binding drug shown to reduce niacin-induced vasodilation and flushing side effects.
Inositol nicotinate, also known as inositol hexanicotinate or inositol hexaniacinate, is a compound of niacin (vitamin B3) and inositol. It is marketed in the United States as a "no-flush" form of niacin in dietary supplements. [1]
Taking 325 mg of aspirin 20–30 minutes prior to taking nicotinic acid has also been proven to prevent flushing in 90% of patients, presumably by suppressing prostaglandin synthesis, [4] but this medication also increases the risk of gastrointestinal bleeding, [5] though the increased risk is less than 1 percent.
Niacin as a nutrient has several benefits, especially when it’s taken at low doses. “It is essential for energy metabolism, neurological function, and the maintenance of healthy skin ...
The body also converts niacin and the amino acid tryptophan into NAD, says Martens — these are both found in some foods and available as supplements, but may not be as effective.
Example of a label showing the amount of niacin (Vitamin B3), and specifying to be niacinamide in the ingredient section.. The United States Government adopted the terms niacin and niacinamide in 1942 as alternate names for nicotinic acid and nicotinamide, respectively, and encouraged their use in nontechnical contexts to avoid the public’s confusing them with the nearly unrelated (and toxic ...
Niacin is widely available as a health supplement. It’s also found in a variety of foods, including: Red meat, poultry and fish. Bran, yeast and whole-grain cereals. Peanuts, legumes and seeds. Eggs
As with niacin and related drugs, the most common adverse effects are flushing (associated with prostaglandin D 2 [2]) and gastrointestinal disturbances such as indigestion, which occur in at least 10% of patients. [1] Flushing can be reduced by taking aspirin 20 to 30 minutes before taking acipimox. Palpitations have also been described.
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