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Causes of encephalitis include viruses such as herpes simplex virus and rabies virus as well as bacteria, fungi, or parasites. [1] [2] Other causes include autoimmune diseases and certain medications. [2] In many cases the cause remains unknown. [2] Risk factors include a weak immune system. [2]
Viral encephalitis is inflammation of the brain parenchyma, called encephalitis, by a virus.The different forms of viral encephalitis are called viral encephalitides. It is the most common type of encephalitis and often occurs with viral meningitis.
A: T2-weighted MRI showing multiple necrotic brain abscesses as a result of a Balamuthia mandrillaris infection. B: T1-weighted MRI showing expansion of the brain infection 4 days later Granulomatous amoebic encephalitis ( GAE ) [ 2 ] is a rare, often fatal, subacute-to-chronic central nervous system disease caused by certain species of free ...
Neuroinflammation is widely regarded as chronic, as opposed to acute, inflammation of the central nervous system. [5] Acute inflammation usually follows injury to the central nervous system immediately, and is characterized by inflammatory molecules, endothelial cell activation, platelet deposition, and tissue edema. [6]
Virus infections usually begin in the peripheral tissues, and can invade the mammalian system by spreading into the peripheral nervous system and more rarely the CNS. CNS is protected by effective immune responses and multi-layer barriers, but some viruses enter with high-efficiency through the bloodstream and some by directly infecting the ...
The next stage of the viral life cycle is called viral replication. During this stage, the virus takes over the host cell's machinery to cause the cell to create more viral proteins and assemble more viruses. Once the cell has produced a sufficient number of viruses, the virus enters the viral shedding stage. During this stage, viruses leave ...
It then can result in encephalitis, when inflammation of the brain, produced by infection by the virus, damages nerve cells, which affects signaling of the brain to the body. After the virus enters the body via a mosquito bite, the virus undergoes local replication at the skin site where virus entered the body. A primary spread of virus occurs ...
Typical sites of virus entry into the body: The first steps of viral infection is determined by the site at which the virus implants into the body. This would subsequently dictate the mechanisms of viral pathogenesis. Transmission from a host with an infection to a second host; Entry of the virus into the body; Local replication in susceptible ...