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Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue 40% of the time. It is also known as Abrikossoff's tumor, [1] granular cell myoblastoma, [1] granular cell nerve sheath tumor, [1] and granular cell schwannoma. [1] Granular cell tumors (GCTs) affect females more often than males. [2]
Cellular schwannoma is nearly exclusively made up of a fascicular proliferation of well-differentiated Schwann cells that are cytologically bland, missing Verocay bodies, and just slightly exhibiting Antoni B pattern growth (10% of the tumor area). [12] [13] [14] Local recurrence is Variable (5-40%) and perhaps greater than in normal schwannomas.
Leiomyomatous hamartoma is a hamartoma which appears as a painless, soft polypoid (polyp-like) mass. [1] It usually is found on the tongue, [2] around the nasopalatine foramen, [3] or in the nasopharynx. [4] The lesion is composed of a proliferation of fusiform and spindle smooth muscle cells. [1]
Schwann cells are glial cells that myelinate the axons of nerve cells. Myelin is a lipid covering that speeds the conduction of action potentials. When Schwann cells proliferate out of control in an encapsulation it is called a schwannoma. Although schwannomas are benign they become detrimental when the growing tumor compresses the nerve.
A hamartoma is a mostly benign, [3] local malformation of cells that resembles a neoplasm of local tissue but is usually due to an overgrowth of multiple aberrant cells, with a basis in a systemic genetic condition, rather than a growth descended from a single mutated cell (monoclonality), as would typically define a benign neoplasm/tumor. [4]
Examples of the most common tissues examined by means of a biopsy include oral and sinus mucosa, bone, soft tissue, skin and lymph nodes. [6] Types of biopsies typically used for diagnosing oral and maxillofacial pathology are: Excisional biopsy: A small lesion is totally excised. This method is preferred if the lesions are approximately 1 cm ...
This page was last edited on 31 December 2018, at 22:14 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Cowden syndrome (also known as Cowden's disease and multiple hamartoma syndrome) is an autosomal dominant inherited condition characterized by benign overgrowths called hamartomas as well as an increased lifetime risk of breast, thyroid, uterine, and other cancers. [1]