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Schizophrenia is thought to have a heritable component in some people, but many people who appear to carry schizophrenia-associated genes may not develop the disease. [13] Research has shown that schizophrenia is a polygenic disorder and that genetic vulnerability to schizophrenia is highly multifactorial , caused by the interactions of several ...
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
The basic principle behind psychiatric genetics is that genetic polymorphisms (as indicated by linkage to e.g. a single nucleotide polymorphism) are part of the causation of psychiatric disorders. [1] Psychiatric genetics is a somewhat new name for the old question, "Are behavioral and psychological conditions and deviations inherited?".
'This will turn out to be the most important break in the disease,' the Broad Institute's director Eric Lander said.
Schizophrenia affects around 0.3–0.7% of the general population at some point in life (i.e. lifetime prevalence), [1] or 21 million people worldwide as of 2020 (about one of every 285). [2] By using precise methods in its diagnosis and a large, representative population, schizophrenia seems to occur with relative consistency over time during ...
More recently, with the decoding of the human genome, there had been a focus on identifying specific genes to study the disease. However, the genetics paradigm faced problems with inconsistent, inconclusive, and variable results. The most recent school of thought is studying schizophrenia through epigenetics. [2]
Schizophrenia is a major cause of disability. In 2016, it was classed as the 12th most disabling condition. [236] Approximately 75% of people with schizophrenia have ongoing disability with relapses. [237] Some people do recover completely and others function well in society. [238]
Risk factors for mental illness include psychological trauma, adverse childhood experiences, genetic predisposition, and personality traits. [7] [8] Correlations between mental disorders and substance use are also found to have a two way relationship, in that substance use can lead to the development of mental disorders and having mental disorders can lead to substance use/abuse.
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