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Laboratory studies have suggested that bioidentical progesterone binds primarily to progesterone receptors, while synthetic progestins activate other receptors with a variety of effects. The editors suggested that progesterone may have neutral to positive effects on the cardiovascular system, and induce apoptosis in breast epithelial cells.
Examples of progestogens include natural or bioidentical progesterone as well as progestins such as medroxyprogesterone acetate and norethisterone. [1] Side effects of progestogens include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and changes in liver protein production among others.
Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. [20] It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women.
Rare side effects may include high potassium levels and blood clots (when taken as a combined oestrogen-progestogen pill), among others. [ 4 ] [ 12 ] Drospirenone is a progestin, or a synthetic progestogen , and hence is an agonist of the progesterone receptor , the biological target of progestogens like progesterone . [ 1 ]
Proponents of bioidentical hormone therapy believe that progesterone offers fewer side effects and improved quality of life compared to MPA. [61] The evidence for this view has been questioned; MPA is better absorbed when taken by mouth, with a much longer elimination half-life leading to more stable blood levels [ 62 ] though it may lead to ...
Norgestrel is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. [6] It has weak androgenic activity and no other important hormonal activity. [6] Norgestrel was patented in 1961 and came into medical use, specifically in birth control pills, in ...
Different sources note different incidence of side effects. The most common side effect is breakthrough bleeding. Combined oral contraceptive pills can improve conditions such as dysmenorrhea, premenstrual syndrome, and acne, [105] reduce symptoms of endometriosis and polycystic ovary syndrome, and decrease the risk of anemia. [106]
The FDA first approved the oral contraceptive in 1960. The first oral contraceptive contained 100 to 175 μg of estrogen and 10 mg of progesterone. However, at these levels significant adverse effects were seen and modern preparations contain lower levels of 30 to 50 μg of estrogen and 0.3 to 1 mg of progesterone. [49]