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Sepsis requires immediate treatment with intravenous fluids and antimicrobial medications. [1] [5] Ongoing care and stabilization often continues in an intensive care unit. [1] If an adequate trial of fluid replacement is not enough to maintain blood pressure, then the use of medications that raise blood pressure becomes necessary. [1]
It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. [1] [2] They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity.
People with septic shock are treated with antimicrobial drugs to treat the causative infection. [12] Some sources of infection require surgical intervention including necrotizing fasciitis, cholangitis, abscess, intestinal ischemia, or infected medical devices. [13] Anaphylactic shock is treated with epinephrine. [14]
Antimicrobial use has been common practice for at least 2000 years. Ancient Egyptians and ancient Greeks used specific molds and plant extracts to treat infection. [5]In the 19th century, microbiologists such as Louis Pasteur and Jules Francois Joubert observed antagonism between some bacteria and discussed the merits of controlling these interactions in medicine. [6]
Cefotaxime is an antibiotic used to treat several bacterial infections in humans, other animals, and plant tissue culture. [3] Specifically in humans it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis. [3]
Ceftazidime is used to treat lower respiratory tract, skin, urinary tract, blood-stream, joint, and abdominal infections, and meningitis. [10] Ceftazidime is the first-line treatment for the tropical infection, melioidosis, an important cause of sepsis in Asia and Australia. [11] [12] Labeled indications include the treatment of patients with:
Wide range of infections; penicillin used for streptococcal infections, syphilis, and Lyme disease: Gastrointestinal upset and diarrhea; Allergy with serious anaphylactic reactions; Brain and kidney damage (rare) Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls ...
It is also used in mouthwashes to treat inflammation of the gums . Polyhexanide (polyhexamethylene biguanide, PHMB) is an antimicrobial compound suitable for clinical use in critically colonized or infected acute and chronic wounds. The physicochemical action on the bacterial envelope prevents or impedes the development of resistant bacterial ...