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As a selective beta-3 adrenergic agonist, mirabegron does not cause the cardiovascular adverse effects of other adrenergic agonists that are active at the beta-1 and beta-2 adrenergic receptors. Beta-3 adrenergic agonists activate brown adipose tissue (BAT) and increase energy expenditure , leading to research interest in their development as ...
The chemical structure of Solabegron, a β 3-adrenergic receptor agonist. Mirabegron is a selective β 3-AR agonist that affects the detrusor muscles of the urinary bladder.By stimulation of β 3-AR the contraction of the smooth muscles of the bladder is decreased and the bladder can store more volume of urine at a given time.
Vibegron is, in contrast to other OAB drugs, very selective and leads to a lesser degree of unwanted side effects. Vibegron is found to be a substrate for CYP3A4 in vivo, but does not actually induce or inhibit any of the cytochrome P450 enzymes and is thus less likely to take part in drug–drug interactions (DDI).
The U.S. Food and Drug Administration (FDA) on Thursday approved a new type of prescription pain medication for adults to treat moderate to severe acute pain. The drug, called Journavx ...
If you take one metformin tablet a day, it’s usually recommended that you take it with your evening meal. So, for example, the best time to take metformin 500mg once a day would be after your ...
Placebos are commonly known as the inert drugs — think sugar pills — that researchers use to measure the effects of real drugs. But research shows they can actually improve certain health ...
A depot injection, also known as a long-acting injectable (LAI), is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication.
But people who took 2,000 international units (IU) of vitamin D and did 30 minutes of strength training three times a week (in addition to the 1 gram of omega-3 fatty acids) saw an even greater ...