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Hippuric acid has long been used as an indicator of toluene exposure; [14] however, there appears to be some doubt about its validity. [15] There is significant endogenous hippuric acid production by humans; which shows inter- and intra-individual variation influenced by factors such as diet, medical treatment, alcohol consumption, etc. [15] This suggests that hippuric acid may be an ...
The IDLH value has been set at 10% of the lower explosive limit although other irreversible health effects or impairment ... Toluene: 1885 mg/m 3: 500 ppm: 108883: ...
Inclusion criteria may include factors such as type and stage of disease, the subject’s previous treatment history, age, sex, race, ethnicity. Exclusion criteria concern properties of the study sample, defining reasons for which patients from the target population are to be excluded from the current study sample. Typical exclusion criteria ...
In the 1980s, the European Union began harmonising regulatory requirements. In 1989, Europe, Japan, and the United States began creating plans for harmonisation. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) was created in April 1990 at a meeting in Brussels.
Toluene (/ ˈ t ɒ l. j u iː n /), also known as toluol (/ ˈ t ɒ l. j u. ɒ l , - ɔː l , - oʊ l / ), is a substituted aromatic hydrocarbon [ 15 ] with the chemical formula C 6 H 5 CH 3 , often abbreviated as PhCH 3 , where Ph stands for the phenyl group.
The World Health Organization (WHO) names four toxicity classes: . Class I – a: extremely hazardous; Class I – b: highly hazardous; Class II: moderately hazardous; Class III: slightly hazardous
The permissible exposure limit (PEL or OSHA PEL) is a legal limit in the United States for exposure of an employee to a chemical substance or physical agent such as high level noise. Permissible exposure limits were established by the Occupational Safety and Health Administration (OSHA). Most of OSHA's PELs were issued shortly after adoption of ...
The National Emission Standards for Hazardous Air Pollutants (NESHAP) are air pollution standards issued by the United States Environmental Protection Agency (EPA). The standards, authorized by the Clean Air Act, are for pollutants not covered by the National Ambient Air Quality Standards (NAAQS) that may cause an increase in fatalities or in serious, irreversible, or incapacitating illness.