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Moderna was founded in 2010 by Derrick Rossi, Timothy A. Springer, Kenneth R. Chien, Robert S. Langer, and Noubar Afeyan. [9] Stéphane Bancel , the current CEO, was appointed as CEO in 2011. [ 6 ] [ 10 ] Between 2011 and 2017, Moderna raised $2 billion in venture capital funding.
The Moderna news followed preliminary results from the Pfizer-BioNTech vaccine candidate, BNT162b2, with Moderna demonstrating similar efficacy, but requiring storage at the temperature of a standard medical refrigerator of 2–8 °C (36–46 °F) for up to thirty days or −20 °C (−4 °F) for up to four months, whereas the Pfizer-BioNTech ...
How COVID‑19 vaccines work. The video shows the process of vaccination, from injection with RNA or viral vector vaccines, to uptake and translation, and on to immune system stimulation and effect. Part of a series on the COVID-19 pandemic Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom. COVID-19 (disease) SARS-CoV-2 (virus) Cases Deaths ...
The Moderna COVID-19 vaccine, also known as Spikevax, [318] is an mRNA vaccine [319] produced by the American company Moderna, the U.S. National Institute of Allergy and Infectious Diseases, the U.S. Biomedical Advanced Research and Development Authority, and the Coalition for Epidemic Preparedness Innovations.
Moderna was founded in 2010, based on discovery that pluripotent stem cells can be transformed and reprogrammed. [10] [11] Time magazine cited this pluripotent discovery as one of the top ten medical breakthroughs of the year. [12]
The COVID-19 mRNA vaccines from Moderna and Pfizer–BioNTech had short-term efficacy rates of over 90 percent against the original SARS-CoV-2 virus. Prior to mRNA, drug trials on pathogens other than COVID-19 were not effective and had to be abandoned in the early phases of trials. The reason for the efficacy of the new mRNA vaccines is not clear.
On 18 December 2020, the US FDA granted an EUA for mRNA-1273, the Moderna vaccine. [26] [27] [28] Vaccine manufacturers are awaiting full approvals to name their vaccines. [117] [118] Moderna submitted a request for an EUA for mRNA-1273 to the FDA on 30 November 2020. [119] [120] On 18 December 2020, the FDA granted an EUA for the Moderna ...
A nucleoside-modified messenger RNA (modRNA) is a synthetic messenger RNA (mRNA) in which some nucleosides are replaced by other naturally modified nucleosides or by synthetic nucleoside analogues.