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[3] Rifampicin was discovered in 1965, marketed in Italy in 1968, and approved in the United States in 1971. [5] [6] [7] It is on the World Health Organization's List of Essential Medicines. [8] The World Health Organization classifies rifampicin as critically important for human medicine. [9] It is available as a generic medication. [3]
Serious side effects may include liver problems or Clostridioides difficile associated diarrhea. [3] It is unclear if use during pregnancy is safe. [3] Rifapentine is in the rifamycin family of medication and works by blocking DNA-dependent RNA polymerase. [3] Rifapentine was approved for medical use in the United States in 1998. [2]
Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.
The hope of a fixed-dose combination pill is to increase the likelihood that people will take all of three medications. [5] Also, if people forget to take one or two of their drugs, they might not then develop resistance to the remaining drugs.
Isoniazid/rifampicin, also known as isoniazid/rifampin, is a medication used to treat tuberculosis. [1] It is a fixed dose combination of isoniazid and rifampicin (rifampin). [1] It is used together with other antituberculosis medication. [1] It is taken by mouth. [1] It is on the World Health Organization's List of Essential Medicines. [2]
In November 2013, Ring was founded as Doorbot by Jamie Siminoff. Doorbot was crowdfunded via Christie Street, and raised US$ 364,000, more than the $250,000 requested. [1] [4] [5] Siminoff's team envisioned the product's concept as an "alarm system literally turned inside out" in comparison to other security systems, describing it as a "pre-crime" system. [6]
Iron rings used in a laboratory. An iron ring or ring clamp is an item of laboratory equipment which comprises a conjoined metal ring and radially-extending rod. [1] In some cases, the rod terminates in a screw clamp for attachment to a retort stand or other support; in others, the rod may be attached to a stand by means of a laboratory clamp holder. [2]
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.