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  2. Photolyase - Wikipedia

    en.wikipedia.org/wiki/Photolyase

    These enzymes require visible light (from the violet/blue end of the spectrum) both for their own activation [1] and for the actual DNA repair. [2] The DNA repair mechanism involving photolyases is called photoreactivation. They mainly convert pyrimidine dimers into a normal pair of pyrimidine bases. Photo reactivation, the first DNA repair ...

  3. Excinuclease - Wikipedia

    en.wikipedia.org/wiki/Excinuclease

    This disease can cause light-skin, extreme freckling and facial lesions, as well as preventing the repair of pyrimidine dimers. Diagnosis of this disease is done by measuring the enzyme's level in white blood cells in a blood sample. Symptoms in children include extreme UV sensitivity, excessive freckling, multiple skin cancers and corneal ...

  4. DNA repair - Wikipedia

    en.wikipedia.org/wiki/DNA_repair

    This then allows recruitment of the DNA repair enzyme MRE11, to initiate DNA repair, within 13 seconds. [51] γH2AX, the phosphorylated form of H2AX is also involved in the early steps leading to chromatin decondensation after DNA double-strand breaks. The histone variant H2AX constitutes about 10% of the H2A histones in human chromatin.

  5. Nucleotide excision repair - Wikipedia

    en.wikipedia.org/wiki/Nucleotide_excision_repair

    Nucleotide excision repair is a DNA repair mechanism. [2] DNA damage occurs constantly because of chemicals (e.g. intercalating agents ), radiation and other mutagens . Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR).

  6. This Enzyme Polish Made Buyers’ Skin Look ‘The Best It Ever Has’

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  7. Xeroderma pigmentosum - Wikipedia

    en.wikipedia.org/wiki/Xeroderma_pigmentosum

    Xeroderma pigmentosum (XP) is a genetic disorder in which there is a decreased ability to repair DNA damage such as that caused by ultraviolet (UV) light. [1] Symptoms may include a severe sunburn after only a few minutes in the sun, freckling in sun-exposed areas, dry skin and changes in skin pigmentation. [1]

  8. XPA - Wikipedia

    en.wikipedia.org/wiki/XPA

    Among the repair proteins with which XPA interacts is a protein complex (including the ERCC1 protein) that is capable of incising DNA at sites of damage. [ 6 ] Xpa mutant individuals often show the severe clinical symptoms of xeroderma pigmentosum , a condition involving extreme sensitivity to sunlight and a high incidence of skin cancer.

  9. Retinal vasculopathy with cerebral leukoencephalopathy and ...

    en.wikipedia.org/wiki/Retinal_vasculopathy_with...

    The official name of the TREX1 gene is "three prime repair exonuclease 1". The normal function of the TREX1 gene is to provide instructions for making the 3-prime repair exonuclease 1 enzyme. This enzyme is a DNA exonuclease, which means it trims molecules of DNA by removing DNA building blocks (nucleotides) from the ends of the molecules.

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