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Cannabis plants vary widely, with different strains producing dynamic balances of cannabinoids (THC, CBD, etc.) and yielding markedly different effects. Popular strains are often hybrids of C. sativa and C. indica. The medicinal effects of cannabis are widely studied, and are active topics of research both at universities and private research ...
However, tolerance to psilocybin is a well understood concept, with repeatedly higher doses being needed in order to achieve the same effect, due to the down regulation of 5HT2A receptors. [6] There is also documented cross-tolerance between psilocybin and LSD, meaning that a higher dose of these substances is needed to get the same effect when ...
[30] [31] Besides psilocin, norpsilocin, baeocystin, norbaeocystin, and aeruginascin may also be present, which might result in an entourage effect and modify the effects of magic mushrooms. [ 24 ] [ 28 ] Panaeolus subbalteatus , one species of magic mushroom, had the highest amount of psilocybin compared to the rest of the fruiting body. [ 28 ]
2C-B (4-bromo-2,5-dimethoxyphenethylamine), also known as Nexus, is a synthetic psychedelic drug of the 2C family, mainly used as a recreational drug. [2] [1] [4] It was first synthesized by Alexander Shulgin in 1974 for use in psychotherapy.
The effects of psilocybin are dependent on set and setting and one's expectations. [11] [21] Psilocybin is a prodrug of psilocin. [15] That is, the compound itself is biologically inactive but is quickly converted by the body to psilocin. [15] Psilocybin is transformed into psilocin by dephosphorylation mediated via phosphatase enzymes.
Well, according to Wise, the brain is actually the most powerful sex organ there is—namely because genital stimulation produces so much muscle and nerve information that a tremendous boost in ...
The color of placebo pills is reported to be a factor in their effectiveness, with "hot-colored" (red, yellow, etc.) pills working better as stimulants and "cool-colored" (blue, purple, etc.) pills working better as depressants. This relationship is believed to be a consequence of patient expectations and not a direct effect of the color. [31]
Psilocybe cubensis, commonly known as the magic mushroom, shroom, golden halo, golden teacher, cube, or gold cap, is a species of psilocybin mushroom of moderate potency whose principal active compounds are psilocybin and psilocin.