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DNA profiling is a forensic technique in criminal investigations, comparing criminal suspects' profiles to DNA evidence so as to assess the likelihood of their involvement in the crime. [ 1 ] [ 2 ] It is also used in paternity testing , [ 3 ] to establish immigration eligibility, [ 4 ] and in genealogical and medical research.
Modern DNA analysis is based on the statistical calculation of the rarity of the produced profile within a population. While most well known as a tool in forensic investigations, DNA profiling can also be used for non-forensic purposes such as paternity testing and human genealogy research.
Forensic profiling is generally conducted using datamining technology, as a means by which relevant patterns are discovered, and profiles are generated from large quantities of data. [1] A distinction of forms of profiles that are used in a given context is necessary before evaluating applications of data mining techniques for forensic profiling.
The US government's own Combined DNA Index System (CODIS) database is composed of forensic evidence assessable to local, state, and federal law enforcement officials. This database consists of genetic profiles of approximately 18 million different people, however these are limited to DNA samples from convicted felons and arrestees. [26]
In forensic science, the DNA evidence received for DNA profiling often contains a mixture of more than one person's DNA. DNA profiles are generated using a set procedure, however, the interpretation of a DNA profile becomes more complicated when the sample contains a mixture of DNA.
Sir Alec John Jeffreys, CH FRS MAE [6] (born 9 January 1950) [5] is a British geneticist known for developing techniques for genetic fingerprinting and DNA profiling which are now used worldwide in forensic science to assist police detective work and to resolve paternity and immigration disputes.
Low Copy Number (LCN) is a DNA profiling technique developed by the UK Forensic Science Service (FSS) which has been in use since 1999. [1]In the United Kingdom use of the technique was suspended between 21 December 2007 and 14 January 2008 while the Crown Prosecution Service conducted a review into its use – this suspension has now been lifted.
The Combined DNA Index System (CODIS) is the United States national DNA database created and maintained by the Federal Bureau of Investigation.CODIS consists of three levels of information; Local DNA Index Systems (LDIS) where DNA profiles originate, State DNA Index Systems (SDIS) which allows for laboratories within states to share information, and the National DNA Index System (NDIS) which ...