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  2. Binimetinib - Wikipedia

    en.wikipedia.org/wiki/Binimetinib

    Binimetinib, sold under the brand name Mektovi, is an anti-cancer medication used to treat various cancers. [4] Binimetinib is a selective inhibitor of MEK, a central kinase in the tumor-promoting MAPK pathway. [5] Inappropriate activation of the pathway has been shown to occur in many cancers. [5]

  3. Macrophage - Wikipedia

    en.wikipedia.org/wiki/Macrophage

    Moreover, macrophages serve as a source for many pro-angiogenic factors including vascular endothelial factor (VEGF), tumor necrosis factor-alpha (TNF-alpha), macrophage colony-stimulating factor (M-CSF/CSF1) and IL-1 and IL-6, [97] contributing further to the tumor growth. Macrophages have been shown to infiltrate a number of tumors.

  4. GcMAF - Wikipedia

    en.wikipedia.org/wiki/GcMAF

    GcMAF (or Gc protein-derived macrophage activating factor) is a protein produced by modification of vitamin D-binding protein. [1] It has been falsely promoted as a treatment for various medical conditions, but claims of its benefits are not supported by evidence.

  5. Immunostimulant - Wikipedia

    en.wikipedia.org/wiki/Immunostimulant

    Immunostimulants, also known as immunostimulators, are substances (drugs and nutrients) that stimulate the immune system usually in a non-specific manner by inducing activation or increasing activity of any of its components. One notable example is the granulocyte macrophage colony-stimulating factor. The goal of this stimulated immune response ...

  6. List of therapeutic monoclonal antibodies - Wikipedia

    en.wikipedia.org/wiki/List_of_therapeutic...

    CSF1, macrophage colony stimulating factor (MCSF) cancer Ladiratuzumab vedotin [26] mab: humanized: LIV-1: cancer Lampalizumab [15] Fab: humanized: Complement factor D (CFD) geographic atrophy secondary to age-related macular degeneration Lanadelumab [41] Takhzyro: mab: human: kallikrein: Y: angioedema: Landogrozumab [12] mab: humanized: GDF-8 ...

  7. Macrophage colony-stimulating factor - Wikipedia

    en.wikipedia.org/wiki/Macrophage_colony...

    The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which causes hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection.

  8. Colony stimulating factor 1 receptor - Wikipedia

    en.wikipedia.org/wiki/Colony_stimulating_factor...

    Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded by the human CSF1R gene (known also as c-FMS).

  9. Tumor necrosis factor - Wikipedia

    en.wikipedia.org/wiki/Tumor_necrosis_factor

    Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. [6]

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