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A major measure of kidney function is the glomerular filtration rate ( GFR ). The glomerular filtration rate is the flow rate of filtered fluid through the kidney. The creatinine clearance rate ( CCr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR.
The normal range of GFR, adjusted for body surface area, is 100–130 average 125 (mL/min)/(1.73 m 2) in men and 90–120 (mL/min)/(1.73 m 2) in women younger than the age of 40. In children, GFR measured by inulin clearance is 110 (mL/min)/(1.73 m 2 ) until 2 years of age in both sexes, and then it progressively decreases.
A glomerular filtration rate (GFR) ≥ 60 mL/min/1.73 m 2 is considered normal without chronic kidney disease if there is no kidney damage present. Kidney damage is defined signs of damage seen in blood, urine, or imaging studies which includes lab albumin/creatinine ratio (ACR) ≥ 30. [ 58 ]
Chronic: 1 per 1,000 (US) [ 1] Kidney failure, also known as end-stage renal disease ( ESRD ), is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. [ 2] Kidney failure is classified as either acute kidney failure, which develops rapidly and may ...
Serum creatinine (a blood measurement) is an important indicator of kidney health, because it is an easily measured byproduct of muscle metabolism that is excreted unchanged by the kidneys. Creatinine itself is produced [ 5] via a biological system involving creatine, phosphocreatine (also known as creatine phosphate), and adenosine ...
Nephritic syndrome, cirrhosis, severe malnutrition [ 2] Treatment. Directed at underlying cause [ 1] Frequency. 5 per 100,000 per year [ 3][ 4] Nephrotic syndrome is a collection of symptoms due to kidney damage. This includes protein in the urine, low blood albumin levels, high blood lipids, and significant swelling.
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