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Insulin aspart, sold under the brand name NovoLog, among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes. [17] It is generally used by injection under the skin but may also be used by injection into a vein . [ 17 ]
Angioedema is an area of swelling of the lower layer of skin and tissue just under the skin or mucous membranes. [1] [3] The swelling may occur in the face, tongue, larynx, abdomen, or arms and legs. [1] Often it is associated with hives, which are swelling within the upper skin. [1] [3] Onset is typically over minutes to hours. [1]
Swollen legs, feet and ankles are common in late pregnancy. The problem is partly caused by the weight of the uterus on the major veins of the pelvis . It usually clears up after delivery of the baby, and is mostly not a cause for concern, [ 16 ] though it should always be reported to a doctor.
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Individuals affected by RS3PE typically have repeated episodes of inflammation of the lining of their synovial joints and swelling of the end portion of the limbs. [8] The arms and hands are more commonly affected than the legs and feet. [8] Both sides are usually involved though RS3PE can affect only one side in certain cases. [8]
Hepatitis (liver swelling) Stomatitis (mouth swelling) Liver failure; Pulmonary oedema (fluid in the lungs) Gastrointestinal bleeding; Pulmonary embolism; Myocardial ischaemia (lack of blood supply to the heart muscles) Speech disorders; Haemoglobin decrease; Proteinuria (protein in the urine; usually indicative of kidney damage)
In the lungs, the extra fluid accumulates into the air sacs within the lung, causing difficulties in oxygen getting into the blood. This results in low blood oxygen levels and shortness of breath. In the arms and legs, the fluid accumulates in the tissues, causing swelling. This is most prominent in the legs due to the effects of gravity.
Swelling: Some individuals may experience slight swelling (edema) in the lower legs alongside the rash. This swelling is typically mild and localized to the affected areas. [3] [2] Burning sensation: A burning or stinging sensation in the affected skin is commonly reported. This discomfort can range from mild to moderate in intensity. [3] [6]
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