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In pharmacokinetics, the rate of infusion (or dosing rate) refers not just to the rate at which a drug is administered, but the desired rate at which a drug should be administered to achieve a steady state of a fixed dose which has been demonstrated to be therapeutically effective. Abbreviations include K in, [1] K 0, [2] or R 0.
Formula Worked example value Dose: Amount of drug administered. ... Infusion rate: Rate of infusion required to balance elimination. / 50 mmol/h Area under the curve ...
In pharmacokinetics, a maintenance dose is the maintenance rate [mg/h] of drug administration equal to the rate of elimination at steady state. This is not to be confused with dose regimen, which is a type of drug therapy in which the dose [mg] of a drug is given at a regular dosing interval on a repetitive basis.
k s is the rate of synthesis or infusion Although these equations were derived to assist with predicting the time course of drug action, [ 1 ] the same equation can be used for any substance or quantity that is being produced at a measurable rate and degraded with first-order kinetics.
The required loading dose may then be calculated as = For an intravenously administered drug, the bioavailability F will equal 1, since the drug is directly introduced to the bloodstream.
This concept is used when the rate of removal is roughly exponential. [ 6 ] In a medical context, half-life explicitly describes the time it takes for the blood plasma concentration of a substance to halve ( plasma half-life ) its steady-state when circulating in the full blood of an organism .
In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry [1]).
The elimination rate constant K or K e is a value used in pharmacokinetics to describe the rate at which a drug is removed from the human system. [1] It is often abbreviated K or K e. It is equivalent to the fraction of a substance that is removed per unit time measured at any particular instant and has units of T −1.