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In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. [3] A trough level is contrasted with a "peak level" (C max), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is ...
Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...
At a practical level, a drug's bioavailability can be defined as the proportion of the drug that reaches the systemic circulation. From this perspective the intravenous administration of a drug provides the greatest possible bioavailability, and this method is considered to yield a bioavailability of 1 (or 100%). Bioavailability of other ...
Depending on context, wave height may be defined in different ways: For a sine wave, the wave height H is twice the amplitude (i.e., the peak-to-peak amplitude): [1] =.; For a periodic wave, it is simply the difference between the maximum and minimum of the surface elevation z = η(x – c p t): [1] = {()} {()}, with c p the phase speed (or propagation speed) of the wave.
A trough is an elongated area of lower air pressure. Since pressure is closely linked to wind, there are often changes in wind direction across a trough. If a trough forms in the mid-latitudes, a temperature difference at some distance between the two sides of the trough usually exists and the trough might become a weather front at some
Significant wave height H m0, defined in the frequency domain, is used both for measured and forecasted wave variance spectra.Most easily, it is defined in terms of the variance m 0 or standard deviation σ η of the surface elevation: [6] = =, where m 0, the zeroth-moment of the variance spectrum, is obtained by integration of the variance spectrum.
A trough is the opposite of a crest, so the minimum or lowest point of the wave. When the crests and troughs of two sine waves of equal amplitude and frequency intersect or collide, while being in phase with each other, the result is called constructive interference and the magnitudes double (above and below the line).
Peak-to-peak amplitude (abbreviated p–p or PtP or PtoP) is the change between peak (highest amplitude value) and trough (lowest amplitude value, which can be negative). With appropriate circuitry, peak-to-peak amplitudes of electric oscillations can be measured by meters or by viewing the waveform on an oscilloscope .