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Kava or kava kava (Piper methysticum: Latin 'pepper' and Latinized Greek 'intoxicating') is a plant in the pepper family, native to the Pacific Islands. [1] The name kava is from Tongan and Marquesan, meaning 'bitter.’ [1] Other names for kava include ʻawa (), [2] ʻava (), yaqona or yagona (), [3] sakau (), [4] seka (), [5] and malok or malogu (parts of Vanuatu). [6]
Liver toxicity, allergic reaction, anaphylaxis [3] Kava: awa, kava-kava [4] Piper methysticum: Potentiates CNS sedatives, [3] chronic use might cause a reversible dry skin condition. [18] Khat: qat Catha edulis: Chronic liver dysfunction [3] [19] Kratom: Mitragyna speciosa: Hepatotoxicity [20] [19] Liquorice root Glycyrrhiza glabra
Kavalactones are a class of lactone compounds found in kava roots and Alpinia zerumbet (shell ginger). [1] and in several Gymnopilus, Phellinus and Inonotus fungi. [2] Some kavalactones are bioactive. They are responsible for the psychoactive, analgesic, euphoric and sedative effects of kava. [3] [4]
The herb kava has caused a number of cases of idiosyncratic liver injury, ranging everywhere from asymptomatic to fatal. Oral use of the antifungal ketoconazole has been associated with hepatic toxicity, including some fatalities; [10] however, such effects appear to be limited to doses taken over a period longer than 7 days. [11]
A sicko from New Jersey allegedly took part in a neo-Nazi child-porn ring whose members groomed children online and extorted them to send self-produced, sexually-explicit videos, federal ...
Moderate cannabis use may still have side effects. Recent cannabis use was associated with poor performance on working memory and motor (movement) tasks, researchers found, but this link went away ...
A major new study has revealed a long list of benefits and some little-known risks of Ozempic and other GLP-1 medications. Experts break down the findings.
Kava Kava (Piper methysticum) extracts: Meta analysis does not suggest efficacy of Kava extracts due to few data available yielding inconclusive results or non-statistically significant results. [69] Nearly a quarter (25.8%) of subjects experienced adverse effects (AEs) from Kava Kava extracts during six trials. [69] Kava Kava may cause liver ...