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Furthermore, several newer studies have documented the substantial benefits of cold exposure in multiple species including humans, for example researchers concluded that "activation of brown adipose tissue is a powerful therapeutic avenue to ameliorate hyperlipidaemia and protect from atherosclerosis" [30] and that brown fat activation reduces ...
22227 Ensembl ENSG00000109424 ENSMUSG00000031710 UniProt P25874 P12242 RefSeq (mRNA) NM_021833 NM_009463 RefSeq (protein) NP_068605 NP_033489 Location (UCSC) Chr 4: 140.56 – 140.57 Mb Chr 8: 84.02 – 84.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial ...
A new study in mice looks at how activating healthy brown fat could help promote weight loss and protect against obesity.
Activation cascade of thermogenin in cells of brown adipose tissue. Non-shivering thermogenesis occurs in brown adipose tissue (brown fat) [3] that is present in almost all eutherians (swine being the only exception currently known [4] [5]). [6]
Antonio Vidal-Puig, Spanish scientist. Antonio Vidal-Puig (born Valencia, Spain June 12, 1962) is a Spanish medical doctor and scientist who works as a Professor of Molecular Nutrition and Metabolism at the University of Cambridge (), best known for advancing the concept that pharmacological targeting of brown fat may serve to treat overweight and obesity in affected individuals, [1] as well ...
The activation of PPAR gamma by these and other ligands may be responsible for inhibiting the growth of cultured human breast, gastric, lung, prostate and other cancer cell lines. [21] [22] During embryogenesis, PPARG first substantially expresses in interscapular brown fat pad. [23]
PRDM16 activates brown fat cell identity and can control the determination of brown adipose fate. A knock-out of PRDM16 in mice shows a loss of brown cell characteristics, showing that PRDM16 activity is important in determining brown adipose fate. [9] Brown adipocytes consist of densely packed mitochondria that contain uncoupling protein 1 ...
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