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Neural stem cells (NSCs) are self-renewing, multipotent cells that firstly generate the radial glial progenitor cells that generate the neurons and glia of the nervous system of all animals during embryonic development. [1] Some neural progenitor stem cells persist in highly restricted regions in the adult vertebrate brain and continue to ...
The brain is the central organ of the human nervous system, and with the spinal cord, comprises the central nervous system. It consists of the cerebrum, the brainstem and the cerebellum. The brain controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sensory nervous system.
Neurogenesis is the process by which nervous system cells, the neurons, are produced by neural stem cells (NSCs). [1] This occurs in all species of animals except the porifera (sponges) and placozoans. [2] Types of NSCs include neuroepithelial cells (NECs), radial glial cells (RGCs), basal progenitors (BPs), intermediate neuronal precursors ...
Cerebral organoid. A neural, or brain organoid, describes an artificially grown, in vitro, tissue resembling parts of the human brain. Neural organoids are created by culturing pluripotent stem cells into a three-dimensional culture that can be maintained for years. [1][2] The brain is an extremely complex system of heterogeneous tissues and ...
Adult neurogenesis is the process in which neurons are generated from neural stem cells in the adult. This process differs from prenatal neurogenesis. In most mammals, new neurons are born throughout adulthood in two regions of the brain: [3] The subgranular zone (SGZ), part of the dentate gyrus of the hippocampus, [4][5] where neural stem ...
Development of the cerebral cortex. The development of the cerebral cortex, known as corticogenesis is the process during which the cerebral cortex of the brain is formed as part of the development of the nervous system of mammals including its development in humans. The cortex is the outer layer of the brain and is composed of up to six layers.
Neuronal precursor cells proliferate in the ventricular zone of the developing neocortex, where the principal neural stem cell is the radial glial cell. The first postmitotic cells must leave the stem cell niche and migrate outward to form the preplate, which is destined to become Cajal–Retzius cells and subplate neurons. These cells do so by ...
Adult stem cells, also called somatic (from Greek σωματικóς, "of the body") stem cells, are stem cells which maintain and repair the tissue in which they are found. [44] There are three known accessible sources of autologous adult stem cells in humans: Bone marrow, which requires extraction by harvesting, usually from pelvic bones via ...
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