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A second form of inhibition can occur from the mimicry of the transition state. The GlcNAcstatin family of inhibitors exploit this mechanism in order to inhibit OGA activity. For both types of inhibitors, OGA can be selected apart from the generic lysosomal hexosaminidases by elongating the C2 substituent in their chemical structure.
OGT cleaves Host Cell Factor C1, at one or more of 6 repeating 26 amino acid sequences. The TPR domain of OGT binds to the carboxyl terminal portion of an HCF1 proteolytic repeat so that the cleavage region is in the glycosyltransferase active site above uridine-diphosphate-GlcNAc [11] The large proportion of OGT complexed with HCF1 is necessary for HCF1 cleavage, and HCFC1 is required for OGT ...
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A dancing drummer wearing a Namahage costume, performed Namahage-Daiko in Akita Station.. The Namahage (生剥げ, なまはげ) [1] are demonlike beings portrayed by men wearing hefty oni (ogre) masks and traditional straw capes during a New Year's ritual, in local northern Japanese folklore of the Oga Peninsula area of Akita Prefecture.
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