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The Lewis antigen system is a human blood group system. It is based upon two genes on chromosome 19: FUT3, or Lewis gene; and FUT2, or Secretor gene. Both genes are ...
The term human blood group systems is defined by the International Society of Blood Transfusion (ISBT) as systems in the human species where cell-surface antigens—in particular, those on blood cells—are "controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them", [1] and include the common ABO and Rh ...
Colton antigen system; Complement component 4; Complement receptor 1; D. Decay-accelerating factor; ... Lewis antigen system; LU domain; Lutheran antigen system; M.
The I and i antigens are carbohydrate structures composed of repeating units of N-acetyllactosamine (LacNAc), and are located on the interior of structures carrying ABH and Lewis antigens. [1] [3] LacNAc repeats are made by the enzymes B3GNT1 and B4GALT1. [4] The i antigen is made of linear repeats, while the structure of the I antigen is ...
This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides during the final step of Lewis antigen biosynthesis. It encodes an enzyme with both alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities.
Carbohydrate antigen 19-9 (CA19-9), also known as sialyl-Lewis A, is a tetrasaccharide which is usually attached to O-glycans on the surface of cells. It is known to play a role in cell-to-cell recognition processes. It is also a tumor marker used primarily in the management of pancreatic cancer. [1]
Blood compatibility testing is routinely performed before a blood transfusion.The full compatibility testing process involves ABO and RhD (Rh factor) typing; screening for antibodies against other blood group systems; and crossmatching, which involves testing the recipient's blood plasma against the donor's red blood cells as a final check for incompatibility.
The LW blood system was first described by Landsteiner and Wiener in 1940. [1] It was often confused with the Rh system, not becoming a separate antigen system until 1982. The LW and RhD antigens are genetically independent though they are phenotypically related and the LW antigen is expressed more strongly on RhD positive cells than on RhD negative cells.