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FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.
The FXR was the base model with solid black paint and laced wheels. The FXRS was the deluxe model with two tone paint, lowered suspension, mag wheels and a backrest. The FXR chassis was essentially an FLT Tour Glide chassis with slightly bigger diameter frame tubes and a more conventional design around the steering head. [10]
Super Glide II FXR 82 cu in (1,340 cc) 1982–1985 Sport Glide FXRT 82 cu in (1,340 cc) 1983–1993 Super glide II FXRS 82 cu in (1,340 cc) [4] 1982–1988 Low Glide ...
Fexaramine is an investigational compound which acts as an agonist of the farnesoid X receptor (FXR), which is a bile acid-activated nuclear receptor that controls bile-acid synthesis, conjugation and transport, as well as lipid metabolism through actions in the liver and intestine.
Read up on the brand's bestsellers below and take a look through the other sale styles to see if there's a shoe that fit your tastes. Allbirds. Allbirds Tree Runners. $68 $98 Save $30.
“Hot Ones” is going solo. BuzzFeed announced a deal to sell First We Feast, the studio behind the popular YouTube chicken-wing-eating celebrity talk show “Hot Ones,” for $82.5 million in ...
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