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This ensures that the cytosolic concentration of free calcium in resting muscle is below 0.1 μM. The sarcoplasmic and endoplasmic reticulum calcium pumps are closely related in structure and mechanism, and both are inhibited by the tumor-promoting agent thapsigargin, which does not affect the plasma membrane Ca 2+ pumps.
Persistent PMCA2 expression in certain breast cancers lowers calcium levels inside malignant cells, allowing them to avoid apoptosis. These tumors are also usually positive for the HER2 protein , tend to involve the lymph nodes , and are more common among young women, which could help explain their worse prognosis compared with postmenopausal ...
The most common cause of primary hyperparathyroidism is a sporadic, single parathyroid adenoma [5] resulting from a clonal mutation (~97%). Less common are parathyroid hyperplasia [6] (~2.5%), parathyroid carcinoma (malignant tumor), and adenomas in more than one gland (together ~0.5%).Primary hyperparathyroidism is also a feature of several familial endocrine disorders: Multiple endocrine ...
9.94 × 10 4 y: ε: 41 K: 42 Ca 0.647% ... Calcium is a chemical element; it has symbol Ca and atomic number 20. ... Excess intake of calcium may cause hypercalcemia ...
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This gene encodes Ca v 3.2, a T-type member of the α 1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of α 1, α 2 δ, β, and γ subunits in a 1:1:1:1 ratio.
A substance of very high concern (SVHC) is a chemical substance (or part of a group of chemical substances) which has been proposed as a candidate for inclusion on the Authorization or Restriction list (see: ECHA Lists) of REACH. [1]
Calcium: Incidence rates of calcium deficiency in children aged 0 to 3, 4 to 9 years and 10 to 15 years were estimated at 10.4%, 6.1% and 0.4% for boys and at 3.4%, 1.7% and 0.9% among girls. It has been found that special diets that are inappropriate for children with ASD usually result in excessive amounts of certain nutrients and persistent ...