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Unlike other "accelerated aging diseases", such as Werner syndrome, Cockayne syndrome, or xeroderma pigmentosum, progeria may not be directly caused by defective DNA repair. These diseases each cause changes in a few specific aspects of aging but never in every aspect at once, so they are often called "segmental progerias". [30]
Misrepair-accumulation aging theory [88] [89] suggests that the abnormality of tissue structure is the common point between premature aging and normal aging. [90] Premature aging is a result of Mis-construction during development as a consequence of gene mutations, whereas normal aging is a result of accumulation of Misrepairs for the survival ...
Werner syndrome patients exhibit growth retardation, short stature, premature graying of hair, alopecia (hair loss), wrinkling, prematurely aged faces with beaked noses, skin atrophy (wasting away) with scleroderma-like lesions, lipodystrophy (loss of fat tissues), abnormal fat deposition leading to thin legs and arms, and severe ulcerations around the Achilles tendon and malleoli (around ankles).
In addition, early life exposures were shown to influence aging and risk of premature death decades down the line. Factors such as body weight at 10 years old and maternal smoking around birth ...
Premature aging occurs when the typical signs of growing older appear early, ... "Many things can cause accelerated skin aging ... first and foremost, ultraviolet radiation exposure. The sun will ...
Using that data, researchers analyzed the influence of nearly 165 environmental elements and genetic risk factors across 22 major age-related diseases and incidences of premature death.
On the other hand, mice defective in one particular DNA repair pathway show clear premature aging, but do not have elevated mutation. [54] One variation of the idea that mutation is the basis of aging, that has received much attention, is that mutations specifically in mitochondrial DNA are the cause of aging.
The impact of alcohol on aging is multifaceted. Evidence shows that alcoholism or alcohol abuse can cause both accelerated (or premature) aging – in which symptoms of aging appear earlier than normal – and exaggerated aging, in which the symptoms appear at the appropriate time but in a more exaggerated form. [1]