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  2. Cialis and Alcohol: Is it Safe?

    www.aol.com/cialis-alcohol-safe-115800912.html

    PDE5 drug interactions with alcohol are more likely to happen with excessive drinking. ... You have an increased risk of side effects, like low blood pressure, if you drink more than five drinks ...

  3. Cialis Side Effects: What to Expect (& How to Avoid Them) - AOL

    www.aol.com/cialis-side-effects-expect-avoid...

    The potential side effects and interactions of Cialis are the same whether it’s used for ED or BPH, so it is important to be aware of these effects before using this medication. A Final Word on ...

  4. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain . [ 2 ]

  5. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]

  6. Tadalafil: Your Ultimate Guide to Dosages, Side Effects & More

    www.aol.com/tadalafil-ultimate-guide-dosages...

    Taking tadalafil (Cialis) with alcohol may increase your risk of developing side effects, including reduced blood pressure. Alcohol can also affect your performance and ability to maintain arousal ...

  7. Andexanet alfa - Wikipedia

    en.wikipedia.org/wiki/Andexanet_alfa

    Andexanet alfa, sold under the brand name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. [8] It has not been found to be useful for other factor Xa inhibitors. [9] It is given by injection into a vein. [9]

  8. Alcohol and High Blood Pressure: What You Should Know

    www.aol.com/alcohol-high-blood-pressure-know...

    Untreated high blood pressure is a major risk factor for heart attack and stroke. Quitting alcohol or drinking moderately may help keep your numbers where they need to be, according to the ...

  9. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.

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