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Isoniazid has a boxed warning for severe and sometimes fatal hepatitis, which is age-dependent at a rate of 0.3% in people 21 to 35 years old and over 2% in those over age 50. [16] [28] Symptoms suggestive of liver toxicity include nausea, vomiting, abdominal pain, dark urine, right upper quadrant pain, and loss of appetite. [16]
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Side effects may include trouble sleeping and weight gain. [2] While there are concerns that use during pregnancy results in a 0.2% increased risk of neural tube defects in the baby, this does not rule out its use. [2]
Management of tuberculosis refers to techniques and procedures utilized for treating tuberculosis (TB), or simply a treatment plan for TB.. The medical standard for active TB is a short course treatment involving a combination of isoniazid, rifampicin (also known as Rifampin), pyrazinamide, and ethambutol for the first two months.
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It combines isoniazid, pyridoxine, sulfamethoxazole, and trimethoprim. [1] Specifically it is used to prevent tuberculosis , toxoplasmosis , pneumonia , malaria , and isosporiasis . [ 2 ] It is taken by mouth .
In latent tuberculosis it is typically used with isoniazid. [2] It is taken by mouth. [2] Common side effects include low neutrophil counts in the blood, elevated liver enzymes, and white blood cells in the urine. [3] Serious side effects may include liver problems or Clostridioides difficile associated diarrhea. [3]
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