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Trimethobenzamide is marketed under the brand names Tebamide and Tigan, manufactured by GlaxoSmithKline and King Pharmaceuticals, respectively.It is available as oral capsules and injectable formulations.
Although QT interval prolongation is one of the most common reasons for drug withdrawal from the market, the overall incidence of drug-induced QT prolongation is difficult to estimate. [13] One study in France estimated that between 5-7% of reports of ventricular tachycardia , ventricular fibrillation , or sudden cardiac death were in fact due ...
An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer. They may be used for severe cases of gastroenteritis, especially if the patient is dehydrated. [1] [2]
Thiethylperazine (Torecan, Norzine) is an antiemetic [1] of the phenothiazine class. It is an antagonist of dopamine receptors (DRD1, DRD2, DRD4) as well as of 5-HT 2A, 5-HT 2C receptors, mAChRs (1 through 5), α 1 adrenergic receptor and H 1 receptor. Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains ...
5-HT 3 receptor antagonists or serotonin antagonists were first introduced in the early 1990s, and they have become the most widely used antiemetic drugs in chemotherapy. [29] They have also been proven safe and effective for treatment of postoperative nausea and vomiting. [30]
Diphenhydramine also has antiemetic properties, ... prolong the QT interval, ... Although diphenhydramine is widely used and generally considered to be safe for ...
Metopimazine is an approved prescription drug in France under the brand name Vogalene® [8] that has been used for the treatment of nausea and vomiting. [9] Vogalene® is available under different forms, including 15 mg capsules, 7.5 mg orally disintegrating tablets, 5 mg suppository, 0.1% oral liquid, and a 10 mg/mL intravenous (IV) solution approved for the prevention of chemotherapy-induced ...
However, itopride does not have any adverse effect on the QT interval. [ 7 ] Later, in a study conducted with healthy adult volunteers, itopride was shown as unlikely to cause cardiac arrhythmias or ECG changes in part to the lack of significant interaction and metabolism via the cytochrome P450 enzyme pathway, unlike cisapride and mosapride ...