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Pilocarpine stimulates the secretion of large amounts of saliva and sweat. [16] It is used to prevent or treat dry mouth, particularly in Sjögren syndrome, but also as a side effect of radiation therapy for head and neck cancer. [17] It may be used to help differentiate Adie syndrome from other causes of unequal pupil size. [18] [19]
Patients can lessen the effects of xerostomia with breath mints, sugarless gum, or lozenges; or physicians can increase saliva flow with artificial saliva or oral pilocarpine. [39] Artificial saliva mimics the characteristics of natural saliva by lubricating and protecting the mouth, but does not provide any digestive or enzymatic benefits. [ 40 ]
Xerostomia is a very common symptom. A conservative estimate of prevalence is about 20% in the general population, with increased prevalences in females (up to 30%) and the elderly (up to 50%). [8] Estimates of the prevalence of persistent dry mouth vary between 10 and 50%. [8]
The following are used in dentistry to treat xerostomia: [3] Parasympathomimetic drugs act on parasympathetic muscarinic receptors to induce an increased saliva flow. The M3 receptor has been identified as the principal target to increase salivary flow rates. [4] Pilocarpine is an example; the maximum dose of this drug is 30 mg/day ...
Chronic dry mouth is prevalent in a high proportion of the elderly population, affecting roughly one fifth of the group. [25] There has been a link between dry mouth and comorbid diseases including diabetes , Alzheimer's or Parkinson's disease [ 14 ] [ 16 ] Additionally, xerostomia can arise from general dehydration . [ 26 ]
It is used in the treatment of dry mouth and Sjögren's syndrome. Medical uses ... Pilocarpine — a similar parasympathomimetic medication for dry mouth ...
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Pilocarpine is a drug that acts as a muscarinic receptor agonist that is used to treat glaucoma Cevimeline (AF102B) (Evoxac®) is a muscarinic agonist that is a Food and Drug Administration (FDA)- approved drug and used for the management of dry mouth in Sjögren's syndrome
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