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End organ damage is severe impairment of major body organs due to systemic disease. Commonly this is referred to in diabetes , high blood pressure , or states of low blood pressure or low blood volume. [ 1 ]
Neuromuscular junction (motor end-organ) Lamellar corpuscle (Pacinian corpuscle end-organ) The ultimately affected organ in a chain of events, such as a disease process (pathophysiology) or a drug's mechanism of action (sometimes called a target organ in this sense) End organ damage, disease of such organs Ambulatory blood pressure § Target ...
Cardiovascular system damage can include myocardial ischemia/infarction, acute left ventricular dysfunction, acute pulmonary edema, and aortic dissection. Other end-organ damage can include acute kidney failure or insufficiency, retinopathy, eclampsia, lung cancer, brain cancer, leukemia and microangiopathic hemolytic anemia. [citation needed]
Vascular obstruction and inflammation caused by gas bubbles causes end organ damage to most tissues. [15] Sufficient pressure difference and expansion to cause this injury can occur from depths as shallow as 1.2 metres (3.9 ft). [16]
Heart: systolic and diastolic heart failure, likely due to chemical signals that depress myocyte function, cellular damage, manifest as a troponin leak (although not necessarily ischemic in nature) More specific definitions of end-organ dysfunction exist for SIRS in pediatrics. [53]
Septic shock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defines septic shock as a subset of sepsis ...
Arterial dissections become life-threatening when growth of the false lumen prevents perfusion of the true lumen and the related end organs. For example, in an aortic dissection, if the left subclavian artery orifice were distal to the origin of the dissection, then the left subclavian would be said to be perfused by the false lumen, while the left common carotid (and its end organ, the left ...
Pre-eclampsia is a multi-system disorder specific to pregnancy, characterized by the new onset of high blood pressure and often a significant amount of protein in the urine or by the new onset of high blood pressure along with significant end-organ damage, with or without the proteinuria.