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Glutethimide is a Schedule II drug under the Convention on Psychotropic Substances. [10] It was originally a Schedule III drug in the United States under the Controlled Substances Act, but in 1991 it was upgraded to Schedule II, [11] several years after it was discovered that misuse combined with codeine increased the effect of the codeine and deaths had resulted from the combination.
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Rogletimide, also known as pyridoglutethimide, is a medication which was never marketed. [1] It is related in chemical structure to the sedative/hypnotic drug glutethimide, but instead has pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide and has no significant sedative-hypnotic effect. [2]
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This is the list of Schedule II controlled substances in the United States as defined by the Controlled Substances Act. [1] The following findings are required, by section 202 of that Act, for substances to be placed in this schedule:
Aminoglutethimide (AG), sold under the brand names Elipten, Cytadren, and Orimeten among others, is a medication which has been used in the treatment of seizures, Cushing's syndrome, breast cancer, and prostate cancer, among other indications.
Pyrithyldione [1] (Presidon, Persedon) is a psychoactive drug invented in 1949. [2] An improved method of manufacture was patented by Roche in 1959. [3] It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates. [4]
Gamma-aminobutyric acid, a GABA-B receptor agonist. A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1]