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  2. Recombinant AAV mediated genome engineering - Wikipedia

    en.wikipedia.org/wiki/Recombinant_AAV_mediated...

    Recombinant adeno-associated virus (rAAV) based genome engineering is a genome editing platform centered on the use of recombinant AAV vectors that enables insertion, deletion or substitution of DNA sequences into the genomes of live mammalian cells.

  3. Self-complementary adeno-associated virus - Wikipedia

    en.wikipedia.org/wiki/Self-Complementary_Adeno...

    Self-complementary adeno-associated virus (scAAV) is a viral vector engineered from the naturally occurring adeno-associated virus (AAV) to be used as a tool for gene therapy. [1] Use of recombinant AAV (rAAV) has been successful in clinical trials addressing a variety of diseases. [ 2 ]

  4. Adeno-associated virus - Wikipedia

    en.wikipedia.org/wiki/Adeno-associated_virus

    Because of AAV's specialized gene therapy advantages, researchers have created an altered version of AAV termed self-complementary adeno-associated virus (scAAV). Whereas AAV packages a single strand of DNA and must wait for its second strand to be synthesized, scAAV packages two shorter strands that are complementary to each other.

  5. Are you ‘competent and caring?’ Then Elon Musk’s ... - AOL

    www.aol.com/news/competent-caring-then-elon-musk...

    Elon Musk’s Department of Government Efficiency has appealed to “competent” and “caring” people to join the cost-cutting team.. Applications to join the billionaire’s newly formed ...

  6. Switzerland 11, Austria 0: Rival powerhouses enter ski worlds ...

    www.aol.com/switzerland-11-austria-0-rival...

    VIENNA (AP) — Switzerland 11, Austria 0. The contrast between the two rival powerhouses of ski racing could hardly be bigger heading into the Alpine world championships in Saalbach-Hinterglemm ...

  7. Notre Dame feels angry and motivated after loss of College ...

    www.aol.com/notre-dame-feels-angry-motivated...

    Notre Dame linebacker Drayk Bowen (34) is consoled on the bench after the Fighting Irish lost to Ohio State in the College Football Playoff championship game at Mercedes-Benz Stadium.

  8. Gene targeting - Wikipedia

    en.wikipedia.org/wiki/Gene_targeting

    Genetic modification usually describes the insertion of a transgene (foreign DNA, i.e. a gene from another species) into a random location within the genome. [ 13 ] [ 14 ] Gene-targeting is a specific biotechnological tool that can lead to small changes to the genome at a specific site [ 2 ] - in which case the edits caused by gene-targeting ...

  9. Oncolytic AAV - Wikipedia

    en.wikipedia.org/wiki/Oncolytic_AAV

    It was found that AAV genome inserts in less than ~10% of occasions AAV infects a cell and the expression is less than when episomally expressed. [4] AAV can only package genomes between 2 – 5.2 kb in size when they are flanked with inverted terminal repeat sequences (ITRs), but optimally holds a genome of 4.1 to 4.9 kb in length. [ 5 ]