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The American Cancer Society also stated that "natural" and "bioidentical" hormones present the same risks as synthetic hormone replacement therapy such as heart disease, blood clots, strokes and an increased risk of breast cancer with long-term use.
Those who started hormone therapy later in life were already at risk of heart problems and cancer, says Dr. Pinkerton, which skewed the results and made hormone therapy seem more dangerous than it ...
There is a non-statistically significant increased rate of breast cancer for hormone replacement therapy with synthetic progestogens. [6] The risk may be reduced with bioidentical progesterone, [69] though the only prospective study that suggested this was underpowered due to the rarity of breast cancer in the control population.
[1] [2] Because estradiol esters are prodrugs of estradiol, they are considered to be natural and bioidentical forms of estrogen. [2] [1] [6] Estrogen esters are used in hormone therapy, hormonal contraception, and high-dose estrogen therapy (e.g., for prostate cancer and breast cancer), among other indications.
regulated bioidentical hormones, which are authorised as they are seen as safe and effective in treating menopause symptoms Speak to a doctor or pharmacist if you are considering complementary ...
In a previous review, the increase in breast cancer risk was found to not be significantly different between these three progestogens. [142] Conversely, there is no significant increase in risk of breast cancer with bioidentical progesterone (OR = 1.00) or with the atypical progestin dydrogesterone (OR = 1.10). [142]
The increase in breast cancer risk with estrogen and progestogen therapy was shown to be causal with conjugated estrogens plus medroxyprogesterone acetate in the Women's Health Initiative randomized controlled trials. [122] [155] Breast cancer risk with combined estrogen and progestogen therapy may differ depending on the progestogen used.
Breast cancer death rate among women: reduced from 23.2 per 100,000 in 2010 to 19.6 per 100,000 in 2020. Colorectal cancer death rate: reduced from 16.2 per 100,000 in 2010 to 12.3 per 100,000 in ...
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