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Mammalian cochlear hair cells are of two anatomically and functionally distinct types, known as outer, and inner hair cells. Damage to these hair cells results in decreased hearing sensitivity , and because the inner ear hair cells cannot regenerate , this damage is permanent. [ 4 ]
The hair cells are the primary auditory receptor cells and they are also known as auditory sensory cells, acoustic hair cells, auditory cells or cells of Corti. The organ of Corti is lined with a single row of inner hair cells and three rows of outer hair cells. The hair cells have a hair bundle at the apical surface of the cell.
For one, the tall hair cell is very similar in function to that of the inner hair cell, and the short hair cell, lacking afferent auditory-nerve fiber innervation, resembles the outer hair cell. One unavoidable difference, however, is that while all hair cells are attached to a tectorial membrane in birds, only the outer hair cells are attached ...
The outer hair cells (OHC) are minimally innervated by spiral ganglion in slow (unmyelinated) reciprocal communicative bundles (30+ hairs per nerve fiber); this contrasts with inner hair cells (IHC) that have only afferent innervation (30+ nerve fibers per one hair) but are heavily connected. There are three to four times as many OHCs as IHCs.
The organ of Corti is located in the scala media of the cochlea of the inner ear between the vestibular duct and the tympanic duct and is composed of mechanosensory cells, known as hair cells. [2] Strategically positioned on the basilar membrane of the organ of Corti are three rows of outer hair cells (OHCs) and one row of inner hair cells ...
Prestin is the motor protein of the outer hair cells of the inner ear of the mammalian cochlea. [15] [16] It is found in the hair cells of all vertebrates, including fish, but are thought to have initially been membrane transporter molecules. A high concentration of prestin are found only in the lateral membranes of therian outer hair cells ...
In this study, scientists used zebrafish to examine the motion of proteins within live ear cells using a confocal microscope. This has shown that proteins in stereocilia move quickly, indicating that the movement of the proteins within the hair cells may be a very important factor to maintaining the integrity of the hair bundles in the inner ear.
Cochlear hair cells are organized as inner hair cells and outer hair cells; inner and outer refer to relative position from the axis of the cochlear spiral. The inner hair cells are the primary sensory receptors and a significant amount of the sensory input to the auditory cortex occurs from these hair cells.