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Detomidine is an imidazole derivative and α 2-adrenergic agonist, [1] used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride . It is a prescription medication available to veterinarians sold under various trade names.
In dogs, sheep, horses, and cattle, the half-life is very short: only 1.21– 5.97 minutes. Complete elimination of the drug can take up to 23 minutes in sheep and up to 49 minutes in horses. [1] [3] In young rats the half-life is one hour. [18] Xylazine has a large volume of distribution of V d = 1.9 – 2.5 for horses, cattle, sheep, and dogs ...
It is normally injected intramuscularly, though can also be injected intra-articularily (directly into the joint) in horses or subcutaneously in off-label uses. [2] Giving PSGAG intra-articularily requires it to be given aseptically, [8] and is sometimes supplemented by the antibiotic amikacin to prevent infection. [1] [3] [7]
In horses, this includes gastric ulcers, [8] right dorsal colitis, [9] and nephrotoxicity. [10] Flunixin is a prohibited substance under International Federation for Equestrian Sports rules, [11] and its use is prohibited or restricted by many other equestrian organizations. At labeled dose (1.1 mg/kg) given IV, detection time was found to be ...
Horses accidentally getting into stored feed and eating too much at one time is a common but preventable way that horses develop colic or laminitis. (see Illnesses related to improper feeding below) It is generally not safe to give a horse feed that was contaminated by the remains of a dead animal. This is a potential source of botulism. [53]
Equine drug testing is a form of drug testing applied to performance horses in regulated competition. Most common in racehorses, drug tests are also performed on horses in endurance riding and in international competition such as the Olympics and FEI-sanctioned competition.
In general, a horse is more likely to survive if it is small in stature and has a good temperament that will tolerate the months of inactivity required for healing. Fractures that are open, comminuted (very fragmented), or located higher on the limb tend to have a poorer prognosis. [2]
The term dosage form may also sometimes refer only to the pharmaceutical formulation of a drug product's constituent substances, without considering its final configuration as a consumable product (e.g., capsule, patch, etc.). Due to the somewhat ambiguous nature and overlap of these terms within the pharmaceutical industry, caution is ...