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  2. Myeloproliferative neoplasm - Wikipedia

    en.wikipedia.org/wiki/Myeloproliferative_neoplasm

    Myeloproliferative neoplasms (MPNs) are a group of rare blood cancers in which excess red blood cells, white blood cells or platelets are produced in the bone marrow. Myelo refers to the bone marrow, proliferative describes the rapid growth of blood cells and neoplasm describes that growth as abnormal and uncontrolled.

  3. Acute megakaryoblastic leukemia - Wikipedia

    en.wikipedia.org/.../Acute_megakaryoblastic_leukemia

    Acute megakaryoblastic leukemia (AMKL) is life-threatening leukemia in which malignant megakaryoblasts proliferate abnormally and injure various tissues. Megakaryoblasts are the most immature precursor cells in a platelet-forming lineage; they mature to promegakaryocytes and, ultimately, megakaryocytes which cells shed membrane-enclosed particles, i.e. platelets, into the circulation.

  4. Leukemia - Wikipedia

    en.wikipedia.org/wiki/Leukemia

    Leukemia (also spelled leukaemia; pronounced / l uː ˈ k iː m iː ə / [1] loo-KEE-mee-ə) is a group of blood cancers that usually begin in the bone marrow and produce high numbers of abnormal blood cells. [9]

  5. Essential thrombocythemia - Wikipedia

    en.wikipedia.org/wiki/Essential_thrombocythemia

    Platelets derived from the abnormal megakaryocytes are activated, which, along with the elevated platelet count, contributes to the likelihood of forming blood clots. [8] The increased possibility of bleeding when the platelet count is over 1 million is due to von Willebrand factor (vWF) sequestration by the increased mass of platelets, leaving ...

  6. Thrombopoietin receptor - Wikipedia

    en.wikipedia.org/wiki/Thrombopoietin_receptor

    The ligand for c-mpl, thrombopoietin, was cloned in 1994.Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cyto

  7. Acute lymphoblastic leukemia (ALL) 4.0% Acute myeloid leukemia (AML) 8.7% Chronic lymphocytic leukemia (CLL) sorted under lymphomas according to current WHO classification; called small lymphocytic lymphoma (SLL) when leukemic cells are absent. 10.2% Chronic myelogenous leukemia (CML) 3.7% Acute monocytic leukemia (AMoL) 0.7% Other leukemias 3.1%

  8. List of hematologic conditions - Wikipedia

    en.wikipedia.org/wiki/List_of_hematologic_conditions

    Accelerated phase chronic myelogenous leukemia: Acute myeloid leukemia: C92.0: 203: Acute myeloid leukemia (AML), also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal ...

  9. Plateletpheresis - Wikipedia

    en.wikipedia.org/wiki/Plateletpheresis

    Platelet transfusions are traditionally given to patients undergoing chemotherapy for leukemia, multiple myeloma, those with aplastic anemia, AIDS, hypersplenism, idiopathic thrombocytopenic purpura (ITP), sepsis, bone marrow transplant, radiation treatment, organ transplant or surgeries such as cardiopulmonary bypass.

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