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Catechol (/ ˈ k æ t ɪ tʃ ɒ l / or / ˈ k æ t ɪ k ɒ l /), also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula C 6 H 4 (OH) 2. It is the ortho isomer of the three isomeric benzenediols .
The 5 substrates of this enzyme are anthranilate, NADH, NADPH, H +, and O 2, whereas its 5 products are catechol, CO 2, NAD +, NADP +, and NH 3. This enzyme belongs to the family of oxidoreductases , specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen.
Figure 1. The overall reaction of catechol 1,2-dioxygenase. Using a non-heme iron(III) complex, 1,2-CTD is able to oxidatively cleave catechol into cis,cis-muconic acid. More specifically, 1,2-CTD is an intradiol dioxygenase, a family of catechol dioxygenases that cleaves the bond between the phenolic hydroxyl groups of catechol using an Fe 3 ...
Catechol dioxygenases are metalloprotein enzymes that carry out the oxidative cleavage of catechols.This class of enzymes incorporate dioxygen into the substrate.Catechol dioxygenases belong to the class of oxidoreductases and have several different substrate specificities, including catechol 1,2-dioxygenase (EC 1.13.11.1), catechol 2,3-dioxygenase (EC 1.13.11.2), and protocatechuate 3,4 ...
Thus, the two substrates of this enzyme are cis-1,2-dihydrobenzene-1,2-diol and NAD +, whereas its 3 products are catechol, NADH, and H +. This enzyme belongs to the family of oxidoreductases , specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor.
Catechol ethers (5 C, 71 P) Catecholamines (5 C, 51 P) Pages in category "Catechols" ... D. Diapocynin; Dihydrexidine; Dihydrogossypetin; 2,3-Dihydroxybenzoic acid;
In the second step, the semiquinone is reduced into a quinone dianion. 9,10-Anthraquinone-2,7-disulphonic acid (AQDS) a quinone similar to one found naturally in rhubarb has been used as a charge carrier in metal-free flow batteries .
Nebicapone (developmental code name BIA 3-202) is a catechol O-methyltransferase (COMT) inhibitor which was under development for the treatment of Parkinson's disease but was never marketed. [ 1 ] [ 2 ] It is a nitrocatechol and is structurally related to entacapone , nitecapone , and tolcapone . [ 2 ]