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The plague endured until about 180 and another epidemic, possibly related, is reported by Dio Cassius to have struck the city of Rome in 189. Two thousand people in the city often died on a single day. Whether this new epidemic, or recurrence of the Antonine plague, impacted the empire outside the city of Rome is unknown. [24]
Death toll (estimate) Ref. 1350 BC plague of Megiddo c. 1350 BC Megiddo, land of Canaan: Amarna letters EA 244, Biridiya, mayor of Megiddo complains to Amenhotep III of his area being "consumed by death, plague and dust" Unknown [29] Hittite Plague/"Hand of Nergal" c. 1330 BC Near East, Hittite Empire, Alashiya, possibly Egypt
While the original origin of the plague is unknown, it possibly entered the Roman Empire via Gothic invasions on the Danube rather than traveling up the Nile from inner Africa. [22] Although no exact figures are known, the death toll was large, with estimates that the population of Alexandria alone dropped from 500,000 to 190,000 during the plague.
Plague, one of the deadliest bacterial infections in human history, caused an estimated 50 million deaths in Europe during the Middle Ages when it was known as the Black Death.
1 Ten deadliest natural disasters by highest estimated death toll excluding epidemics and famines. ... Antonine Plague: Roman Empire: 165–180 (possibly up to 190)
The Antonine Plague of 165–180 CE, ... The death toll was enormous; throughout the world around 50 million people died from the infection. [193]
Gaul is known to have suffered severely from the plague, [20] and plague victims at an early Anglo-Saxon burial site at Edix Hill near Cambridge show that it also reached Britain. [21] Procopius said that plague sufferers experienced delusions, nightmares, fevers, swellings in the groin, armpits and behind the ears, and coma or death. [22]
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