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  2. Nikolsky's sign - Wikipedia

    en.wikipedia.org/wiki/Nikolsky's_sign

    It is also associated with pemphigus vulgaris and pemphigus foliaceus. [6] [7] It is useful in differentiating between the diagnosis of pemphigus vulgaris or mucous membrane pemphigoid (where the sign is present) and bullous pemphigoid (where it is absent). The Nikolsky sign is dislodgement of intact superficial epidermis by a shearing force ...

  3. Asboe-Hansen sign - Wikipedia

    en.wikipedia.org/wiki/Asboe-Hansen_sign

    [2] [3] It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions. [ 4 ] This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.

  4. Autoimmune skin diseases in dogs - Wikipedia

    en.wikipedia.org/wiki/Autoimmune_skin_diseases...

    For Pemphigus vulgaris, after the skin begins to separate, Nikolsky's sign can be useful to help diagnose the disease. This involves placing pressure along the edge of a blister and observing if the skin separates further and if the blister increases in size. [21]

  5. Pemphigus vulgaris - Wikipedia

    en.wikipedia.org/wiki/Pemphigus_vulgaris

    Pemphigus vulgaris is a rare chronic blistering skin disease and the most common form of pemphigus.Pemphigus was derived from the Greek word pemphix, meaning blister. [1] It is classified as a type II hypersensitivity reaction in which antibodies are formed against desmosomes, components of the skin that function to keep certain layers of skin bound to each other.

  6. List of eponymous medical signs - Wikipedia

    en.wikipedia.org/.../List_of_eponymous_medical_signs

    Sign Name Specialty ... Nikolsky's sign: Pyotr Nikolsky: dermatology: various, including pemphigus vulgaris: shearing of epidermis under pressure O'Brien's test?

  7. Mucous membrane pemphigoid - Wikipedia

    en.wikipedia.org/wiki/Mucous_membrane_pemphigoid

    Nikolsky's sign (gentle lateral pressure) on unaffected mucosa or skin raises a bulla. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion. In contrast, in Pemphigus, the epithelium tends to disintegrate rather than form a bulla.

  8. Bullous pemphigoid - Wikipedia

    en.wikipedia.org/wiki/Bullous_pemphigoid

    Nikolsky's sign is negative, unlike pemphigus vulgaris, where it is positive. [4] Causes. In most cases of bullous pemphigoid, no clear precipitating factors are ...

  9. Staphylococcal scalded skin syndrome - Wikipedia

    en.wikipedia.org/wiki/Staphylococcal_scalded...

    SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).