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The long term use of levodopa increases oxidative stress through monoamine oxidase led enzymatic degradation of synthesized dopamine causing neuronal damage and cytotoxicity. The oxidative stress is caused by the formation of reactive oxygen species (H 2 O 2 ) during the monoamine oxidase led metabolism of dopamine.
Mucuna pruriens is a tropical legume native to Africa and tropical Asia and widely naturalized and cultivated. [2] Its English common names include monkey tamarind , velvet bean , Bengal velvet bean , Florida velvet bean , Mauritius velvet bean , Yokohama velvet bean , cowage , cowitch , lacuna bean , and Lyon bean . [ 2 ]
Antenatal steroids have also been shown to have definite beneficial effect in treating the condition of preterm premature rupture of membranes (PPROM). [8] Similar to its effects on preterm birth, research evidence suggests that the administration of antenatal steroids to patients with PPROM reduces risks of neonatal mortality, intraventricular hemorrhage and respiratory distress syndrome.
Umbilical cord blood gas analysis may assist with clinical management and excludes the diagnosis of birth asphyxia in approximately 80% of depressed newborns at term. [27] Severe fetal growth issues in conjunction with low oxygen in the fetus’ blood and high levels in the mother’s blood also indicate the use of PUBS. [28]
The hairy pods of Mucuna poggei. The proteolytic enzyme mucunain is a protein in the tissues of certain legumes of the genus Mucuna, especially velvet bean (Mucuna pruriens). [1] [2] [3] In these species the mucunain is found in stiff hairs, or trichomes, covering the seed pods. When the hairs rub off and come in contact with skin they cause ...
Mucuna is a genus of around 114 accepted species of climbing lianas (vines) and shrubs of the family Fabaceae: tribe Phaseoleae, typically found in tropical and subtropical forests in the Americas, sub-Saharan Africa, southern, southeastern, and eastern Asia, New Guinea, Australia, and the Pacific Islands.
Bufotenin has been identified as a component in the latex of the takini (Brosimum acutifolium) tree, which is used as a psychedelic by South American shamans, [25] and in the seeds of Mucuna pruriens. [26] Bufotenin has also been identified in Amanita muscaria, Amanita citrina, A. porphyria, and A. tomentella. [27] [28]
There are few side effects, other than vomiting, with short-term use. [1] [2] With long-term use anemia or numbness may occur. [2] It should always be given with at least 21% oxygen. [2] It is not recommended in people with a bowel obstruction or pneumothorax. [2] Use in the early part of pregnancy is not recommended. [1]
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