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Oral contraceptive pills have contradictory results from different studies regarding any effect of decreasing relapse rate in women with multiple sclerosis. [77] Certain medications for MS symptoms, such as carbamazepine (used to treat spasms and pain) and modafinil (used to treat fatigue) can make oral contraceptive pills less effective. [77]
Prescription drug list prices in the United States continually are among the highest in the world. [1] [2] The high cost of prescription drugs became a major topic of discussion in the 21st century, leading up to the American health care reform debate of 2009, and received renewed attention in 2015.
This may be because of lack of funding to go through the approval process. Some doctors prescribe them off-label or under the schema of open label research. Examples of MS drugs used off label include: rituximab - Monoclonal antibody against CD20. According to some sources it has a better efficacy vs. safety profile than most approved drugs. [76]
High prices for specialty drugs are a problem for both patients and payers. Patients frequently have difficulty paying for these medications, which can lead to lack of access to treatment. [57] Specialty drugs are now so expensive that they are leading to increases in insurance premiums. [58]
Ocrelizumab, sold under the brand name Ocrevus, is a medication used for the treatment of multiple sclerosis. It is a humanized anti- CD20 monoclonal antibody . [ 8 ] It targets CD20 marker on B lymphocytes and is an immunosuppressive drug . [ 10 ]
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
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