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2. Discovery and development of HIV-protease inhibitors

   en.wikipedia.org/wiki/Discovery_and_development...

   HIV infection was first described in 1981 in San Francisco and New York City. [7] In 1985, HIV was identified as the causative agent of acquired immune deficiency syndrome (AIDS) and its complete genome was immediately available. This knowledge paved the way for the development of selective inhibitors. [6]

3. Discovery and development of integrase inhibitors - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   Many drugs have been discovered to treat the disease but mutations in the virus and resistance to the drugs make development difficult. Integrase is a viral enzyme that integrates retroviral DNA into the host cell genome. Integrase inhibitors are a new class of drugs used in the treatment of HIV.

4. New HIV prevention drug could reach poorest countries ... - AOL

   www.aol.com/news/hiv-prevention-drug-could-reach...

   A new long-acting preventive HIV drug could reach the world’s poorest countries by the end of 2025 or early 2026, a global health official told Reuters on Tuesday. The ambition is to start ...

5. Discovery and development of non-nucleoside reverse ...

   en.wikipedia.org/wiki/Discovery_and_development...

   The development of effective anti-HIV drugs is difficult due to wide variations in nucleotide and amino acid sequences. The perfect anti-HIV drug chemical should be effective against drug resistance mutation. Understanding the target RT enzyme and its structure, mechanism of drug action and the consequence of drug resistance mutations provide ...

6. Gilead Unveils New Yearly HIV Injection To Offer Hope for ...

   www.aol.com/gilead-unveils-yearly-hiv-injection...

   At the HIV Analyst & Investor Event on Tuesday, Gilead Sciences Inc. (NASDAQ:GILD) revealed that it is developing a once-yearly injectable formulation for lenacapavir. The annual formulation is ...

7. New Science May Finally Outsmart the HIV Virus - AOL

   www.aol.com/lifestyle/science-may-finally...

   The first HIV drug, which came out in 1987, blocked nucleoside reverse transcriptase, an enzyme HIV uses to replicate. ... and people in the South—the part of the U.S. where new HIV cases are ...

8. Discovery and development of nucleoside and nucleotide ...

   en.wikipedia.org/wiki/Discovery_and_development...

   The reverse transcriptase of HIV-1 has been the main foundation for the development of anti-HIV drugs. [5] The first nucleoside reverse-transcriptase inhibitor with in vitro anti-HIV activity was zidovudine. [6] Since zidovudine was approved in 1987, six nucleosides and one nucleotide reverse-transcriptase inhibitor (NRTI) have been approved by ...

9. A 'miracle' HIV shot, surprising shingles vaccine benefit and ...

   www.aol.com/lifestyle/miracle-hiv-shot...

   A new HIV drug is very promising. A twice-yearly shot from pharmaceutical company Gilead was 100% effective in preventing HIV infections in women, per new research. The study, which involved 5,338 ...