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Although they are called untranslated regions, and do not form the protein-coding region of the gene, uORFs located within the 5' UTR can be translated into peptides. [1] The 5' UTR is upstream from the coding sequence. Within the 5' UTR is a sequence that is recognized by the ribosome which allows the ribosome to bind and initiate translation.
However, the LEI code length of 20 characters represented a problem for many systems, which in practice limited the usable prefix length to 10 characters. In June 2013, ISDA working groups suggested that the characters 7 through 16 of the 20 character global LEI number should be used as the UTI prefix. This would have led to clashes between ...
The Atlas of UTR Regulatory Activity (AURA), [1] a biological database, now at its second version, [2] is a manually curated and comprehensive catalog of human 5' and 3' untranslated sequences (UTR) and UTR regulatory annotations. It includes basic annotation, phylogenetic conservation, binding sites for RNA-binding proteins and miRNA, cis ...
Scientists use a number of methods to study the complex structures and functions of the 3′ UTR. Even if a given 3′-UTR in an mRNA is shown to be present in a tissue, the effects of localization, functional half-life, translational efficiency, and trans-acting elements must be determined to understand the 3′-UTR's full functionality. [7]
The 5′ untranslated region (also known as 5′ UTR, leader sequence, transcript leader, or leader RNA) is the region of a messenger RNA (mRNA) that is directly upstream from the initiation codon. This region is important for the regulation of translation of a transcript by differing mechanisms in viruses , prokaryotes and eukaryotes .
From January 2008 to December 2012, if you bought shares in companies when Larry R. Faulkner joined the board, and sold them when he left, you would have a 1.5 percent return on your investment, compared to a 5.2 percent return from the S&P 500.
In protein-coding genes, the exons include both the protein-coding sequence and the 5′- and 3′-untranslated regions (UTR). Often the first exon includes both the 5′-UTR and the first part of the coding sequence, but exons containing only regions of 5′-UTR or (more rarely) 3′-UTR occur in some genes, i.e. the UTRs may contain introns. [11]
From January 2008 to December 2012, if you bought shares in companies when William B. Harrison, Jr. joined the board, and sold them when he left, you would have a -29.6 percent return on your investment, compared to a -2.8 percent return from the S&P 500.
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