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Schematic overview of the modular structure underlying procedures for gene set enrichment analysis. Gene set enrichment analysis (GSEA) (also called functional enrichment analysis or pathway enrichment analysis) is a method to identify classes of genes or proteins that are over-represented in a large set of genes or proteins, and may have an association with different phenotypes (e.g ...
The Gene Ontology (GO) provides a system for hierarchically classifying genes or gene products into terms organized in a graph structure (or an ontology).The terms are groups into three categories: molecular function (describing the molecular activity of a gene), biological process (describing the larger cellular or physiological role carried out by the gene, coordinated with other genes), and ...
Environmental enrichment affects cognition and intellectual development from a neurobiological perspective. More stimulating environments can increase the number of synapses in the brain which increases synaptic activity. In humans this is most likely to occur during the development of the brain but can also occur in adults.
The solution to this problem is to break these k-mer sized reads into smaller k-mers, such that the resulting smaller k-mers will represent all the possible k-mers of that smaller size that are present in the genome. [27] Furthermore, splitting the k-mers into smaller sizes also helps alleviate the problem of different initial read lengths. In ...
Pathway resources and types of pathway analysis using databases like KEGG, Reactome and WikiPathways. [1]Pathway is the term from molecular biology for a curated schematic representation of a well characterized segment of the molecular physiological machinery, such as a metabolic pathway describing an enzymatic process within a cell or tissue or a signaling pathway model representing a ...
The missing heritability problem was named as such in 2008 (after the "missing baryon problem" in physics).The Human Genome Project led to optimistic forecasts that the large genetic contributions to many traits and diseases (which were identified by quantitative genetics and behavioral genetics in particular) would soon be mapped and pinned down to specific genes and their genetic variants by ...
Environmental enrichment is the stimulation of the brain by its physical and social surroundings. Brains in richer, more stimulating environments have higher rates of synaptogenesis and more complex dendrite arbors , leading to increased brain activity.
GP has been successfully used as an automatic programming tool, a machine learning tool and an automatic problem-solving engine. [18] GP is especially useful in the domains where the exact form of the solution is not known in advance or an approximate solution is acceptable (possibly because finding the exact solution is very difficult).
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