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The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place.
Sulfamethoxazole (SMZ or SMX) is an antibiotic. It is used for bacterial infections such as urinary tract infections, bronchitis, and prostatitis and is effective against both gram negative and positive bacteria such as Escherichia coli and Listeria monocytogenes. [1] Common side effects include nausea, vomiting, loss of appetite, and skin rashes.
Marijuana is already commonly used to alleviate some of the painful symptoms of cancer and chemotherapy, but there's some research suggesting marijuana can actually delay or reduce tumors.
With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. [1] [2] It is taken orally (swallowed by mouth). [1] Common side effects include nausea, changes in taste, and rash. [1] Rarely it may result in blood problems such as not enough platelets or white blood cells. [1] Trimethoprim may cause sun ...
Smoking tobacco doubles the risk of developing head and neck squamous cell carcinoma, which makes up 90% of all head and neck cancers. Heavier tobacco use leads to even higher risk, and when ...
Certain sulfonamides (sulfadiazine or sulfamethoxazole) are sometimes mixed with the drug trimethoprim, which acts against dihydrofolate reductase. As of 2013, the Republic of Ireland is the largest exporter worldwide of sulfonamides, accounting for approximately 32% of total exports. [16]