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A serum folate level of less than 7 nmol/L (3 μg/L) is indicative of folate deficiency; Red blood cell folate testing is not routinely performed, since serum folate is sufficient in most cases, however, if there is a strong suspicion of folate deficiency despite a normal serum folate level, a red cell folate test may be performed.
A serum folate of 3 μg/L or lower indicates deficiency. [98] Serum folate level reflects folate status, but erythrocyte folate level better reflects tissue stores after intake. An erythrocyte folate level of 140 μg/L or lower indicates inadequate folate status. Serum folate reacts more rapidly to folate intake than erythrocyte folate. [113]
Diet improvement is a way to combat nutritional anemia and this can be done by taking dietary supplements such as iron, folate, and Vitamin B12.[2] These supplements are available over-the-counter however, a doctor may prescribe prescription medicine as needed, depending on the patient's health needs.
The un-methylated form, folic acid (vitamin B 9), is a synthetic form of folate, and must undergo enzymatic reduction by dihydrofolate reductase to become biologically active. [1] It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate.
This requires active folate and vitamin B 12, in order to donate a methyl group. Active folate is known as 5-methyltetrahydrofolate (5-MTHF). Another pathway for the conversion of homocysteine back to methionine also exists, involving methylation with trimethylglycine (also called betaine or abbreviated to TMG) as a methyl donor.
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(Folic acid/Folate) – Serum: Age > 1 year: 3.0 [126] 16 [126] 5 [127] ng/mL or μg/L 6.8 [128] 36 [128] 11 [128] nmol/L Vitamin B 9 (Folic acid/Folate) – Red ...
In “The Flip Side of Fear”, we look at some common phobias, like sharks and flying, but also bats, germs and strangers. We tried to identify the origin of these fears and why they continue to exist when logic tells us they shouldn’t.